Patrizia Longone
Academic Editor

Patrizia Longone


Summary

Team Leader of the Molecular Neurobiology Unit, Experimental Neurology, Fondazione Santa Lucia, Rome, Italy.
Adjunct Professor of Physiology for the Graduate Course of Nursing and the Graduate Course of Speech Therapy, University of “Tor Vergata”, Rome, Italy.

Anatomy & Physiology Neuroscience

Work details

Research Team Leader

Fondazione Santa Lucia
Laboratory of Molecular Neurobiology
The research carried out by the Molecular Neurobiology Laboratory focused, in particular, on the role played by glutammatergic excitotoxicity in the degeneration of spinal motoneurons in Amyotrophic Lateral Sclerosis (SLA). The Laboratory has shown that some receptors activated by excitatory glutamate neurotransmitter express different isoforms and subunits in the spinal cord of an experimental model of familial SLA. Primary neuronal cultures and methods of biochemistry and molecular biology were used for the study. We have also shown that these differences make AMPA receptors more active and can depolarize the neuron faster and longer. Using an experimental model of SLA we have shown that alteration of the function and expression of the glutamate matrix alter the shape, number and size of the cortical dendritic spines as well as modify the expression of its receptors and neuronal function. The work was carried out in collaboration with the CNR of Rome and Pisa and with the Experimental Neurology Laboratory of the Santa Lucia Foundation.