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Paul Brookes
PeerJ Editor & Author
605 Points

Contributions by role

Author 270
Editor 335

Contributions by subject area

Biochemistry
Cardiology
Ethical Issues
Science Policy
Anatomy and Physiology
Hematology
Clinical Trials
Oncology
Legal Issues
Statistics
Molecular Biology
Gastroenterology and Hepatology
Pharmacology

Paul S. Brookes

PeerJ Editor & Author

Summary

Professor of Anesthesiology at University of Rochester Medical Center. PhD in Biochemistry from Cambridge University (UK) and post-doctoral training at the University of Alabama at Birmingham. Research program in mitochondria, cardiac ischemia, and cardioprotective therapies.

Biochemistry Cell Biology

Editorial Board Member

PeerJ - the Journal of Life & Environmental Sciences

Past or current institution affiliations

University of Rochester

Work details

Professor

University of Rochester
Anesthesiology
Our broad research interest is cardioprotection against ischemia-reperfusion (IR) injury. We are particularly interested in mechanisms of protection in ischemic preconditioning (IPC), and anesthetic preconditioning (APC) and the role of mitochondria and metabolism in these processes. A variety of model systems are used, including: isolated heart mitochondria, Langendorff perfused mouse hearts, isolated adult mouse cardiomyocytes, in-vivo mouse coronary artery occlusion, and H9c2 cardiomyocytes in cell culture. We also use many biochemical techniques to investigate mitochondrial function including: mitochondrial respiration & membrane potential assays, electrode and fluorescence based measurements of reactive oxygen species (ROS), analysis of protein post-translational modifications (esp. acetylation & S-nitrosation) by 2D gels, western blotting and mass spectrometry, spectrophotometry, fluorescence spectroscopy, Seahorse XF extracellular flux analysis, chemical synthesis and development of novel small molecule therapeutics, and LC-MS based metabolomics. We maintain several lines of engineered mice for these studies.

Websites

  • PubMed Search

PeerJ Contributions

  • Articles 2
  • Edited 1
  • Answers 2
April 3, 2014
Internet publicity of data problems in the bioscience literature correlates with enhanced corrective action
Paul S. Brookes
https://doi.org/10.7717/peerj.313 PubMed 24765564
March 5, 2013
A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel
Andrew P. Wojtovich, Sergiy M. Nadtochiy, William R. Urciuoli, Charles O. Smith, Morten Grunnet, Keith Nehrke, Paul S. Brookes
https://doi.org/10.7717/peerj.48 PubMed 23638385

Academic Editor on

November 12, 2021
Treatment with sodium (S)-2-hydroxyglutarate prevents liver injury in an ischemia-reperfusion model in female Wistar rats
Eduardo Cienfuegos-Pecina, Diana P. Moreno-Peña, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Diana Garza-Villarreal, Oscar H. Mendoza-Hernández, Raul Alejandro Flores-Cantú, Brenda Alejandra Samaniego Sáenz, Gabriela Alarcon-Galvan, Linda E. Muñoz-Espinosa, Tannya R. Ibarra-Rivera, Alma L. Saucedo, Paula Cordero-Pérez
https://doi.org/10.7717/peerj.12426 PubMed 34824916

2 Answers

0
Why are papers in privately questioned papers older than publicly questioned papers?
0
Are publisher identities a possible confounder?