Patrick A Lewis


Summary

My research is focused on understanding the molecular pathways that lead to inherited Parkinson's disease linked to mutations in Leucine rich repeat kinase 2 (LRRK2). Mutations in this gene are the single most common genetic cause of Parkinson's disease, affecting 5-10,000 people in the UK alone. My lab is investigating how these mutations alter cellular function and fate, with a particular interest in macroautophagy and lysosomal biology.

Biochemistry Neuroscience

Institution affiliations

Work details

Associate Professor

University of Reading
School of Pharmacy

University College London

PeerJ Contributions

February 19, 2015
17 citations
597 downloads
2,135 views
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https://doi.org/10.7717/peerj.778 PubMed 25737818