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Nadezhda Orlova
PeerJ Author
135 Points

Contributions by role

Author 135

Contributions by subject area

Biotechnology
Molecular Biology
Virology
COVID-19

Nadezhda A Orlova

PeerJ Author

Summary

Research scientist at the Lab of Mammalian cells bioengineering, Institute of Bioengineering, Research Centre of Biotechnology Russian Academy of Sciences, Moscow, Russia.
Former academic positions: research scientist at the Lab of Medical Biotechnology, National Research Center for Hematology Russian Academy of Medical Sciences, Moscow, Russia; research scientist at the Lab of Biocatalysis, Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia.
Research interests are focused on the development of biotherapeutics production technologies - recombinant protein production and gene therapy. As a PI and co-investigator worked on the development of the mammalian cell lines expressing recombinant human coagulation factors and gonadotropins and the development of the purification methods and QC for the protein preparations.
Ph.D. in molecular biology (2013, Moscow State University, Molecular biology department of the Biological Faculty). Graduated in 2003 from the Moscow State University, Molecular biology department of the Biological faculty.
Member of the Russian Society for Biochemistry and Molecular Biology (RSBMB).

Biochemistry Biotechnology Molecular Biology

Work details

reserch scientist

Research Centre of Biotechnology Russian Academy of Sciences, Institute of Bioengineering
September 2012
Lab of Bioengineering of the Mammalian Cells
Development of recombinant human gonadotropins production technology in CHO cells.

research scientist

National Research Center for Hematology Russian Academy of Medical Sciences
August 2008 - March 2015
Lab of Medical Biotechnology
Development of recombinant coagulation factors production technologies in CHO cells

research scientist

Research scientist, Institute of Bioorganic Chemistry Russian Academy of Sciences,
January 2012 - August 2015
Lab of Biocatalysis
Design of genetic elements and expression system optimization for recombinant proteins expression. Study of bioconjugate drug candidates

Websites

  • Google Scholar
  • ResearcherID
  • Lab site
  • PubMed Search

PeerJ Contributions

  • Articles 3
February 14, 2025
Increased glycoprotein hormone yield in stably transfected CHO cells using human serum albumin signal peptide for beta-chains
Maria V. Sinegubova, Denis E. Kolesov, Ivan I. Vorobiev, Nadezhda A. Orlova
https://doi.org/10.7717/peerj.18908 PubMed 39963195
October 24, 2023
Promoter from Chinese hamster elongation factor-1a gene and Epstein-Barr virus terminal repeats concatemer fragment maintain stable high-level expression of recombinant proteins
Maria V. Sinegubova, Nadezhda A. Orlova, Ivan I. Vorobiev
https://doi.org/10.7717/peerj.16287 PubMed 37901457
January 7, 2022
Antigenic properties of the SARS-CoV-2 nucleoprotein are altered by the RNA admixture
Denis E. Kolesov, Maria V. Sinegubova, Irina V. Safenkova, Ivan I. Vorobiev, Nadezhda A. Orlova
https://doi.org/10.7717/peerj.12751 PubMed 35036106