Graduated from Oxford University in physics and proceeded to a physics PhD at Manchester University. Saw the light and came over to biology through protein structure prediction into genome annotation. Founded the Ensembl database alongside Ewan Birney and Tim Hubbard at the Sanger Institute. Crossed the pond to the Broad Institute where many mammals were sequenced and the human gene count trimmed of its fat. Had a short enjoyable interlude in the commercial sphere at Bioteam and is now residing at Harvard University with fingers in many pies.