Philippe Marambaud

Philippe Marambaud


My research focuses on the molecular basis of neuronal degeneration in Alzheimer's disease. My laboratory studies the early biochemical changes leading to the formation of two classic lesions of the Alzheimer brain, the senile plaques and the neurofibrillary tangles. We currently focus our attention on the role played by the ion channel CALHM1 and the kinase AMPK in the pathogenesis of this disease.

Since 2015, my laboratory has significantly expanded its activities to include programs aimed at studying the vascular disease called hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome. In cell and mouse models for this disease, we seek to increase our understanding of the molecular basis of HHT, but also to identify disease-modifying interventions.

Cell Biology Cognitive Disorders Molecular Biology Neuroscience

Work details

Associate Investigator

The Feinstein Institute for Medical Research
Litwin-Zucker Research Center for the Study of Alzheimer’s Disease
Northwell Health, 350 Community Drive, Manhasset, New York 11030


PeerJ Contributions