My research focuses on the molecular basis of neuronal degeneration in Alzheimer's disease. My laboratory studies the early biochemical changes leading to the formation of two classic lesions of the Alzheimer brain, the senile plaques and the neurofibrillary tangles. We currently focus our attention on the role played by the ion channel CALHM1 and the kinase AMPK in the pathogenesis of this disease.
HEREDITARY HEMORRHAGIC TELANGIECTASIA (HHT)
Since 2015, my laboratory has significantly expanded its activities to include programs aimed at studying the vascular disease called hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome. In cell and mouse models for this disease, we seek to increase our understanding of the molecular basis of HHT, but also to identify disease-modifying interventions.