Lilia M Iakoucheva
Assistant Professor in the Department of Psychiatry at the University of California San Diego, USA. Currently investigates the molecular basis of neurodevelopmental and psychiatric diseases using genomic and systems biology approaches.
Dr. Iakoucheva’s research focuses on understanding of the molecular basis of autism and schizophrenia using systems biology approaches. The aim is to discover functional protein interaction networks connecting seemingly unrelated candidate genes for psychiatric diseases. Dr. Iakoucheva’s lab is building comprehensive protein-protein interaction networks for autism and schizophrenia candidate genes and their splicing isoforms. In addition, they are integrating gene expression data with our experimentally derived networks to understand spatio-temporal dynamics of protein interactions in the brain. Their immediate goal is to investigate perturbations of the disease networks by the Copy Number Variants (CNVs) and protein-damaging Single Nucleotide Variants (SNVs) identified in the patients using the Whole Exome Sequencing (WES) studies. Additionally, they are interested in interpreting non-coding genetic variation with relevance to psychiatric diseases. They are investigating functional impact of UTR, promoter and splice site mutations identified in the Whole Genome Sequencing (WGS) studies of autism and schizophrenia using in vitro cellular systems.