James A.L. Brown

Summary

My major research interest is in how acetylation regulates genome stability, particularly in response to DNA double strand breaks (DSB) in a breast cancer model. My translational work is focused on pre-clinical and early clinical validation of small molecules he developed which target specific lysine acetyltransferases (KATi). Further research interests include investigating and validating novel breast cancer biomarkers (proteins and miRNA), for improved patient stratification and to enhance our understanding of the molecular changes seen in breast cancer. I have a strong research record and I was awarded the prestigious European Association for Cancer Research young scientist award (2015) by the Irish association for Cancer Research (IACR), an award for an outstanding young individual based scientific track record and additionally on my publication in Scientific Reports (Gao et al, 2014), for developing a novel compound that preferentially targets breast cancer.

I was the first Chair of the IACR Junior Council and now sit on the IACR Senior Council. I am an Academic Editor (AE) for PLOS ONE and sit on the Editorial Board of Biochemistry and Molecular Biology Education (BAMBEd).

My postgraduate students (PhD, MD) all have multiple publications and have won a number of awards and grants, and are regularly selected for oral presentations at national and international conferences.

Biochemistry Cell Biology Molecular Biology Oncology Translational Medicine