Ines Perpetuo

Ines P. Perpetuo


Summary

I am currently a Postdoctoral researcher with Michael Doube in the Comparative Biomedical Sciences Department at the Royal Veterinary College, University of London. My work involves activity assays of osteoblasts and osteoclasts isolated and cultured from animals ranging in size from mouse to elephant.

My main focus of research is bone cell biology - differentiation from precursors and activity. I am also interested in understanding osteoclast and osteoblast differentiation and activity, bone resorption and bone formation coupling, inflammation and its implications in bone and other tissues and bone biology as a whole.

I was a PhD student at the Rheumatology Research Unit at Instituto de Medicina Molecular in Lisbon working on osteoclast differentiation and activity in patients with rheumatoid arthritis and ankylosing spondylitis.

Cell Biology Immunology Molecular Biology Rheumatology

Institution affiliations

Work details

Post-doctoral researcher

Royal Veterinary College
May 2015
Skeletal Biology - Comparative Biomedical Sciences
Postdoctoral researcher with Michael Doube in the Comparative Biomedical Sciences Department at the Royal Veterinary College, University of London. My work involves activity assays of osteoblasts and osteoclasts isolated and cultured from animals ranging in size from mouse to elephant.

MSc Student/Researcher/PhD candidate

Instituto de Medicina Molecular
January 2008 - April 2015
Rheumatology Research Unit
PhD project - "Differences in osteoclast activity between rheumatoid arthritis and ankylosing spondylitis" Study the biology of osteoclast differentiation in several rheumatic diseases under different therapies. Additional skills: - Tutoring undergrad students - Co-supervision of Master Students Master in the field of Biological Sciences studying osteoclast differentiation in Rheumatoid Arthritis patients under several therapies. Researcher in several areas including Osteoimmunology, Leucocyte subpopulations, Monocyte frequency and phenotyping and osteoclast differentiation. Primary cell culture - Monocyte differentiation into osteoclasts Bone biology. Inflammation and bone. Osteoclast differentiation from circulating precursors. Gene expression. Intra-cellular signaling and transcriptional regulation. Osteoimmunology 2009- 2011 - Project entitled: "Avaliação do comportamento dos osteoclastos em doenças reumáticas - Osteoclast formation and activity in rheumatic diseases". Investigator in the project "Cardiovascular risk and inflammation- contribution to the etiopathogenesis of atherosclerosis and cardiovascular disease" (PIC/IC/82920/2007) Investigator in the project "Effects of inflammation on bone and cartilage: collagen pattern and biomechanical properties" (PTDC/SAU-BEB/65992/2006) 2008 - working on the project "Chronic joint inflammatory diseases and CD14+CD16+ monocytes – physiopathology implications and future therapeutic targets".