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Howard Young
PeerJ Editor & Reviewer
3,975 Points

Contributions by role

Reviewer 35
Editor 3,940

Contributions by subject area

Immunology
Infectious Diseases
Bioinformatics
Genetics
Molecular Biology
Hematology
Microbiology
Urology
Cardiology
Cell Biology
Food Science and Technology
Pharmacology
Biochemistry
Translational Medicine
Evidence Based Medicine
Computational Biology
Virology
Animal Behavior
Neuroscience
Emergency and Critical Care
Respiratory Medicine
Medical Genetics
Oncology
Public Health
Gastroenterology and Hepatology
Pathology
Epidemiology
HIV
Genomics
Allergy and Clinical Immunology
Nephrology
Rheumatology
Pediatrics
Orthopedics
Zoology
Internal Medicine
Veterinary Medicine
Biotechnology
Metabolic Sciences
Data Mining and Machine Learning
Computational Science
Surgery and Surgical Specialties
Histology
Mycology

Howard A. Young

PeerJ Editor & Reviewer

Summary

Deputy Chief, Laboratory of Experimental Immunology, Frederick National Laboratory for Cancer Research.

Dr. Howard Young obtained his Ph.D. in microbiology at the University of Washington and carried out postdoctoral research at the NCI under Drs. Edward Scolnick and Wade Parks. He was a member of the Laboratory of Molecular Immunoregulation at NCI from 1983 to 1989 prior to joining the Laboratory of Experimental Immunology in 1989. He was President of the International Society for Interferon and Cytokine Research (2004-2005) and served as Chair of the Immunology Division of the American Society for Microbiology. He has also served as Chair of the NIH Cytokine Interest Group and Co-Chair of the NIH Immunology Interest Group. He is a two-time recipient of the NIH Director's Award for Mentoring (2000, 2006) and in 2006 he received the National Public Service Award.

Immunology Infectious Diseases

Editorial Board Member

PeerJ - the Journal of Life & Environmental Sciences

Work details

Senior Investigator

National Cancer Institute at Frederick
April 1980
Cancer and Inflammation
The laboratory studies the control of gene expression during the development and maturation of the cellular immune system in mediating antitumor and anti-inflammatory immune responses. The general goals are to use cellular and molecular approaches to investigate the consequences of persistent exposure to interferon-γ (IFN-γ) and how it alters host physiology. To approach this question, we have generated a novel mouse model where a portion of the 3' untranslated region of the mRNA has been changed, resulting in a much more stable mRNA and this will now permit us to understand the consequences of persistent IFN-γ expression on the host. We have backcrossed this change onto the murine C57BL/6 and Balb/c genetic backgrounds and as a consequence have developed new mouse models for lupus, primary biliary cholangitis and aplastic anemia. These mice are characterized by low but chronic IFN-γ expression. As a result there is persistent upregulation of IFN-γ inducible genes, resulting in the development of autoimmunity. Overall, our studies represent a cellular and molecular analysis of the consequences of aberrant regulation of cytokine gene expression in lymphoid cells and the effects on the host physiology and immune system development and function. Our studies provide a basis for developing a more complete understanding of the effects of IFN-γ expression during the pathogenesis of autoimmune diseases, cancer and infection.

Websites

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  • ResearchGate

PeerJ Contributions

  • Edited 25
  • Reviewed 1

Academic Editor on

August 25, 2023
Characterization of endoplasmic reticulum-associated degradation in the human fungal pathogen Candida albicans
Ellen M. Doss, Joshua M. Moore, Bryce H. Harman, Emma H. Doud, Eric M. Rubenstein, Douglas A. Bernstein
https://doi.org/10.7717/peerj.15897 PubMed 37645016
May 5, 2023
Identification of key immune-related genes associated with LPS/D-GalN-induced acute liver failure in mice based on transcriptome sequencing
Ling Chen, Li Yuan, Jingle Yang, Yizhi Pan, Hong Wang
https://doi.org/10.7717/peerj.15241 PubMed 37168540
May 1, 2023
Novel immune cell infiltration-related biomarkers in atherosclerosis diagnosis
Ruoyu Dong, Jikuan Li, Guangwei Jiang, Ning Han, Yaochao Zhang, Xiaoming Shi
https://doi.org/10.7717/peerj.15341 PubMed 37151293
September 16, 2022
Sex differences in peripheral monoamine transmitter and related hormone levels in chronic stress mice with a depression-like phenotype
Yitian Chen, Weijia Cai, Canye Li, Zuanjun Su, Zhijun Guo, Zhuman Li, Chen Wang, Feng Xu
https://doi.org/10.7717/peerj.14014 PubMed 36132219
August 16, 2022
Chemotherapeutic resistant cholangiocarcinoma displayed distinct intratumoral microbial composition and metabolic profiles
Sirinya Sitthirak, Manida Suksawat, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Sakkarn Sangkhamanon, Watcharin Loilome
https://doi.org/10.7717/peerj.13876 PubMed 35990899
April 20, 2022
Analysis of serum and gene expression profile of cytokines (IL-6, TNF-α and TGF-β1) in chronic hepatitis C virus infection
Ismail Che Noh, Richard Avoi, Asma Abdullah Nurul, Imran Ahmad, Ruzilawati Abu Bakar
https://doi.org/10.7717/peerj.13330 PubMed 35469194
March 21, 2022
Chikungunya virus time course infection of human macrophages reveals intracellular signaling pathways relevant to repurposed therapeutics
Madison Gray, Israel Guerrero-Arguero, Antonio Solis-Leal, Richard A. Robison, Bradford K. Berges, Brett E. Pickett
https://doi.org/10.7717/peerj.13090 PubMed 35341048
February 16, 2022
In vivo evaluation of the protective effects of arjunolic acid against lipopolysaccharide-induced septic myocardial injury
Hany Elsawy, Mohammed Almalki, Omar Elmenshawy, Ashraf Abdel-Moneim
https://doi.org/10.7717/peerj.12986 PubMed 35190789
December 24, 2021
Macrophage immunomodulatory activity of Acanthopanax senticousus polysaccharide nanoemulsion via activation of P65/JNK/ikkαsignaling pathway and regulation of Th1/Th2 Cytokines
Xianghui Li, Zhiqiang Zhang, Zhenhuan Guo, Li Zhao, Yonglu Liu, Xia Ma, Qigai He
https://doi.org/10.7717/peerj.12575 PubMed 35036126
October 26, 2021
Identification and validation of candidate genes dysregulated in alveolar macrophages of acute respiratory distress syndrome
Yong Mao, Xin Lv, Wei Xu, Youguo Ying, Zonghe Qin, Handi Liao, Li Chen, Ya Liu
https://doi.org/10.7717/peerj.12312 PubMed 34754619
August 25, 2021
Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis
Yujia Lan, Erjie Zhao, Xinxin Zhang, Xiaojing Zhu, Linyun Wan, Suru A, Yanyan Ping, Yihan Wang
https://doi.org/10.7717/peerj.12070 PubMed 34527446
June 29, 2021
Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to Brucella Melitensis strain M5-90
Baobao Li, Si Chen, Chengqiang Wang, Qiaoling Chen, Churiga Man, Qi An, Zhenxing Zhang, Zhiyong Liu, Li Du, Fengyang Wang
https://doi.org/10.7717/peerj.11679 PubMed 34249510
February 16, 2021
Immune function of miR-214 and its application prospects as molecular marker
Qiuyuan Wang, Yang Liu, Yiru Wu, Jie Wen, Chaolai Man
https://doi.org/10.7717/peerj.10924 PubMed 33628646
January 19, 2021
Physical activity modulates mononuclear phagocytes in mammary tissue and inhibits tumor growth in mice
Donald M. Lamkin, Karen P. Bradshaw, Janice Chang, Ma’ayan Epstein, Jack Gomberg, Krupa P. Prajapati, Veronica H. Soliman, Thezia Sylviana, Yinnie Wong, Kouki Morizono, Erica K. Sloan, Steve W. Cole
https://doi.org/10.7717/peerj.10725 PubMed 33552733
October 30, 2020
Construction of fibronectin conditional gene knock-out mice and the effect of fibronectin gene knockout on hematopoietic, biochemical and immune parameters in mice
Xiaohong Yuan, Shu Yang, Wen Li, Jinggang Li, Jia Lin, Yong Wu, Yuanzhong Chen
https://doi.org/10.7717/peerj.10224 PubMed 33194415
August 19, 2020
The long-term outcomes of deceased-donor liver transplantation for primary biliary cirrhosis: a two-center study in China
Lin Chen, Xiaodong Shi, Guoyue Lv, Xiaodong Sun, Chao Sun, Yanjun Cai, Junqi Niu, Jinglan Jin, Ning Liu, Wanyu Li
https://doi.org/10.7717/peerj.9563 PubMed 32879788
October 30, 2019
A bibliometric analysis of IL-35 research from 2009 to 2018
Xulong Cai, Chenrong Zhou, Li Zhou, Qiaolan Xu
https://doi.org/10.7717/peerj.7992 PubMed 31687283
June 25, 2019
Updated advances of linking psychosocial factors and sex hormones with systemic lupus erythematosus susceptibility and development
Qingjun Pan, Xiaoqun Chen, Shuzhen Liao, Xiaocui Chen, Chunfei Zhao, Yong-zhi Xu, Hua-feng Liu
https://doi.org/10.7717/peerj.7179 PubMed 31275761
June 12, 2019
T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection
Zuanhao Qian, Zhenglei Zhang, Yingying Wang
https://doi.org/10.7717/peerj.7089 PubMed 31223533
September 13, 2018
Cytokine and microRNA levels during different periods of paradoxical sleep deprivation and sleep recovery in rats
Malinalli Brianza-Padilla, Fausto Sánchez-Muñoz, Gonzalo Vázquez-Palacios, Fengyang Huang, Julio César Almanza-Pérez, Rafael Bojalil, Herlinda Bonilla-Jaime
https://doi.org/10.7717/peerj.5567 PubMed 30225174
June 14, 2018
Crucial biological functions of CCL7 in cancer
Yangyang Liu, Yadi Cai, Li Liu, Yudong Wu, Xiangyang Xiong
https://doi.org/10.7717/peerj.4928 PubMed 29915688
December 7, 2016
Attenuation of antigen-specific T helper 1 immunity by Neolitsea hiiranensis and its derived terpenoids
Yin-Hua Cheng, Ih-Sheng Chen, Ying-Chi Lin, Chun-Wei Tung, Hsun-Shuo Chang, Chia-Chi Wang
https://doi.org/10.7717/peerj.2758 PubMed 28344896
September 15, 2016
Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets
Wen-Xing Li, Shao-Xing Dai, Qian Wang, Yi-Cheng Guo, Yi Hong, Jun-Juan Zheng, Jia-Qian Liu, Dahai Liu, Gong-Hua Li, Jing-Fei Huang
https://doi.org/10.7717/peerj.2470 PubMed 27672514
September 18, 2014
MicroRNAs expression profile in CCR6+ regulatory T cells
Juanjuan Zhao, Yongju Li, Yan Hu, Chao Chen, Ya Zhou, Yijin Tao, Mengmeng Guo, Nalin Qin, Lin Xu
https://doi.org/10.7717/peerj.575 PubMed 25279261
September 10, 2013
Hypoxia-inducible C-to-U coding RNA editing downregulates SDHB in monocytes
Bora E. Baysal, Kitty De Jong, Biao Liu, Jianmin Wang, Santosh K. Patnaik, Paul K. Wallace, Robert T. Taggart
https://doi.org/10.7717/peerj.152 PubMed 24058882

Signed reviews submitted for articles published in PeerJ Note that some articles may not have the review itself made public unless authors have made them open as well.

January 10, 2017
Interferon-γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission
Cyrus Ayieko, Bilha S. Ogola, Lyticia Ochola, Gideon A.M. Ngwena, George Ayodo, James S. Hodges, Gregory S. Noland, Chandy C. John
https://doi.org/10.7717/peerj.2855 PubMed 28097063