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Mario Alberto Flores-Valdez
Bronze Contributor
5,945 Points

Contributions by role

Editor 5,945

Contributions by subject area

Bioengineering
Biotechnology
Immunology
Infectious Diseases
Genetics
Microbiology
Synthetic Biology
Molecular Biology
Virology
Drugs and Devices
Evidence Based Medicine
Pharmacology
Ecosystem Science
Environmental Sciences
Evolutionary Studies
Agricultural Science
Epidemiology
Gastroenterology and Hepatology
Bioinformatics
Genomics
Public Health
Surgery and Surgical Specialties
Translational Medicine
Veterinary Medicine
Global Health
HIV
Statistics
Emergency and Critical Care
Internal Medicine
Respiratory Medicine
Food Science and Technology
Cell Biology
Oncology
Metabolic Sciences
Biochemistry
Taxonomy
Health Policy
Mathematical Biology
Data Mining and Machine Learning
Parasitology
Biodiversity
Ecology
Zoology
Freshwater Biology
Pediatrics
Plant Science
Mycology
Marine Biology
Climate Change Biology
Biological Oceanography
Dentistry
Aquaculture, Fisheries and Fish Science
Bronze Contributor

Mario Alberto Flores-Valdez

PeerJ Editor & Author

Summary

Dr. Mario Alberto Flores-Valdez is a Professor in the Medical and Pharmaceutical Biotechnology Unit, CIATEJ, A.C., Guadalajara, Jalisco, Mexico (2007-present). He is a member of the National System of Researchers (SNI), and a member of the Mexican Academy of Sciences. He was a Stanford University Medical Center postdoctoral fellow (2004-2007), where he received a Dean's Fellowship Award (2006) to conduct research on Tuberculosis. He worked in UNAM as Research Assistant for Prof. Jaime Mora (2004) and Prof. Emundo Calva (2003). He has received a Ph.D. in Biochemistry from UNAM (1999-2003), a M.Sc. in Molecular Biology and Genetic Engineering from UANL (1996-1999) and a B.Sc. from Universidad de Sonora (1991-1996) in Chemistry and Biology. He received fellowships from CONACYT for M.Sc. and Ph.D. studies and in M.Sc. and B.Sc. has received Diplomas as Best Student. He has expertise in Tuberculosis, particularly in developing recombinant BCG strains. He has been PI for 7 grants from 2008 to date, focused in studies about tuberculosis vaccine development and basic aspects of mycobacterial physiology.

Biochemistry Biotechnology Cell Biology Genetics Genomics Immunology Infectious Diseases Microbiology Molecular Biology Synthetic Biology Translational Medicine Tuberculosis

Editorial Board Member

PeerJ - the Journal of Life & Environmental Sciences

Work details

Research Scientist, level C

Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, A.C.
December 2007
Medical and Pharmaceutical Biotechnology
One of the most significant developments that has occurred in the field of medicine and has had more impact on health is vaccination, preventing innumerable cases of infections every year and saving millions of lives worldwide. Since its inception, vaccinology has been refined through a gradual transition from an empirical science to rational design, accumulated in various disciplines, among which cell biology, biochemistry, immunology and molecular biology have contributed substantially. The most important challenges for modern vaccinology is the immediate response to emerging infectious disease caused by new variants of microorganisms and antigenic variants resistant to antiviral agents and antibiotics as well as prolonging the immune or memory reprogramming response in the case of autoimmune diseases and specific activation of a specific type of response. In response to these needs, the line of development and evaluation of vaccines was created with the goal of applying innovative tools for design, development and optimization of formulations with immunoprotective properties for human and veterinary diseases interest, focusing on the use of new immunogens or mixtures thereof and new modulators or enhancers of the immune response.

Websites

  • ResearchGate
  • Google Scholar
  • CIATEJ profile

PeerJ Contributions

  • Edited 47

Academic Editor on

July 28, 2023
Green synthesis of silver nanoparticles using Ocimum sanctum Linn. and its antibacterial activity against multidrug resistant Acinetobacter baumannii
Deepan Gautam, Karma Gurmey Dolma, Bidita Khandelwal, Madhu Gupta, Meghna Singh, Tooba Mahboob, Anil Teotia, Prasad Thota, Jaydeep Bhattacharya, Ramesh Goyal, Sonia M.R. Oliveira, Maria de Lourdes Pereira, Christophe Wiart, Polrat Wilairatana, Komgrit Eawsakul, Mohammed Rahmatullah, Shanmuga Sundar Saravanabhavan, Veeranoot Nissapatorn
https://doi.org/10.7717/peerj.15590 PubMed 37529215
July 14, 2023
Skin bacterial community differences among three species of co-occurring Ranid frogs
Zachary Gajewski, Leah R. Johnson, Daniel Medina, William W. Crainer, Christopher M. Nagy, Lisa K. Belden
https://doi.org/10.7717/peerj.15556 PubMed 37465150
January 17, 2022
Screening and identification of differentially expressed long non-coding RNAs in multidrug-resistant tuberculosis
Junwei Zhao, ShuHui Gao, Chunguang Chen, Hui Li, Shaohua Wang, Yongmin Yu, Liang Ming
https://doi.org/10.7717/peerj.12776 PubMed 35111403
September 8, 2021
Whole-genome comparative analysis at the lineage/sublineage level discloses relationships between Mycobacterium tuberculosis genotype and clinical phenotype
Andrea Monserrat Negrete-Paz, Gerardo Vázquez-Marrufo, Ma. Soledad Vázquez-Garcidueñas
https://doi.org/10.7717/peerj.12128 PubMed 34589306
July 16, 2021
Structural and immunological characterization of an epitope within the PAN motif of ectodomain I in Babesia bovis apical membrane antigen 1 for vaccine development
Amarin Rittipornlertrak, Boondarika Nambooppha, Anucha Muenthaisong, Veerasak Punyapornwithaya, Saruda Tiwananthagorn, Yang-Tsung Chung, Bumduuren Tuvshintulga, Thillaiampalam Sivakumar, Naoaki Yokoyama, Nattawooti Sthitmatee
https://doi.org/10.7717/peerj.11765 PubMed 34316404
November 3, 2020
Gut microbiota in hospitalized children with acute infective gastroenteritis caused by virus or bacteria in a regional Peruvian hospital
Andre Alonso Taco-Masias, Augusto R. Fernandez-Aristi, Angela Cornejo-Tapia, Miguel Angel Aguilar-Luis, Luis J. del Valle, Wilmer Silva-Caso, Victor Zavaleta-Gavidia, Pablo Weilg, Hernán Cornejo-Pacherres, Jorge Bazán-Mayra, Zully M. Puyen, Juana del Valle-Mendoza
https://doi.org/10.7717/peerj.9964 PubMed 33194370
August 31, 2020
An epidemiological investigation of porcine circovirus type 2 and porcine circovirus type 3 infections in Tianjin, North China
Shuai-Yong Wang, Ying-Feng Sun, Qi Wang, Ling-Xue Yu, Shi-Qiang Zhu, Xiao-Min Liu, Yun Yao, Juan Wang, Tong-Ling Shan, Hao Zheng, Yan-Jun Zhou, Wu Tong, Ning Kong, Guang-Zhi Tong, Hai Yu
https://doi.org/10.7717/peerj.9735 PubMed 32944419
August 7, 2020
High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice
Kirstie M. Mangas, Nicholas J. Tobias, Estelle Marion, Jérémie Babonneau, Laurent Marsollier, Jessica L. Porter, Sacha J. Pidot, Chinn Yi Wong, David C. Jackson, Brendon Y. Chua, Timothy P. Stinear
https://doi.org/10.7717/peerj.9659 PubMed 32844063
July 29, 2020
Metagenomic next-generation sequencing for the clinical diagnosis and prognosis of acute respiratory distress syndrome caused by severe pneumonia: a retrospective study
Peng Zhang, Yan Chen, Shuyun Li, Chaoliang Li, Shuang Zhang, Weihao Zheng, Yantang Chen, Jie Ma, Xin Zhang, Yanming Huang, Shengming Liu
https://doi.org/10.7717/peerj.9623 PubMed 32821543
May 21, 2020
Isolation, characterization, and comparative genomic analysis of a phage infecting high-level aminoglycoside-resistant (HLAR) Enterococcus faecalis
Danial Nasr Azadani, Daiyuan Zhang, J. Robert Hatherill, David Silva, Jeffrey W. Turner
https://doi.org/10.7717/peerj.9171 PubMed 32509458
January 20, 2020
Organic acids and 2,4-Di-tert-butylphenol: major compounds of Weissella confusa WM36 cell-free supernatant against growth, survival and virulence of Salmonella Typhi
Wattana Pelyuntha, Chaiyavat Chaiyasut, Duangporn Kantachote, Sasithorn Sirilun
https://doi.org/10.7717/peerj.8410 PubMed 31998561
November 25, 2019
Peripheral blood bovine lymphocytes and MAP show distinctly different proteome changes and immune pathways in host-pathogen interaction
Kristina J.H. Kleinwort, Stefanie M. Hauck, Roxane L. Degroote, Armin M. Scholz, Christina Hölzel, Erwin P. Maertlbauer, Cornelia Deeg
https://doi.org/10.7717/peerj.8130 PubMed 31788366
November 21, 2019
TLR4 polymorphisms may increase susceptibility to periodontitis in Pg-positive individuals
Wenjing Li, Xiaojing Cao, Lu He, Huanxin Meng, Bingtao Yang, Yanting Liao
https://doi.org/10.7717/peerj.7828 PubMed 31772831
November 20, 2019
Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children’s Hospital in México City in an eight-years survey
Roberto Cabrera-Contreras, Rosa I. Santamaría, Patricia Bustos, Irma Martínez-Flores, Enrique Meléndez-Herrada, Rubén Morelos-Ramírez, Martín Barbosa-Amezcua, Vanessa González-Covarrubias, Eugenia Silva-Herzog, Xavier Soberón, Víctor González
https://doi.org/10.7717/peerj.8068 PubMed 31768302
September 25, 2019
Development of a highly sensitive magneto-enzyme lateral flow immunoassay for dengue NS1 detection
Tien V. Tran, Ba V. Nguyen, Thao T.P. Nguyen, Tung T. Tran, Khanh G. Pham, Quang B. Le, Binh N. Do, Hung N. Pham, Chuyen V. Nguyen, Duong P.H. Dinh, Van T. Ha, Trang H.T. Doan, Hoa Q. Le
https://doi.org/10.7717/peerj.7779 PubMed 31579630
May 15, 2019
Cells released from S. epidermidis biofilms present increased antibiotic tolerance to multiple antibiotics
Vânia Gaio, Nuno Cerca
https://doi.org/10.7717/peerj.6884 PubMed 31143534
May 1, 2019
A large scale evaluation of TBProfiler and Mykrobe for antibiotic resistance prediction in Mycobacterium tuberculosis
Pierre Mahé, Meriem El Azami, Philippine Barlas, Maud Tournoud
https://doi.org/10.7717/peerj.6857 PubMed 31106066
April 12, 2019
Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis
Kochi Toyomane, Yoshikazu Furuta, Daisuke Fujikura, Hideaki Higashi
https://doi.org/10.7717/peerj.6718 PubMed 30997291
March 28, 2019
Evaluation of a toxoid fusion protein vaccine produced in plants to protect poultry against necrotic enteritis
Joseph G.L. Hunter, Shyra Wilde, Amanda M. Tafoya, Jamie Horsman, Miranda Yousif, Andrew G. Diamos, Kenneth L. Roland, Hugh S. Mason
https://doi.org/10.7717/peerj.6600 PubMed 30944775
March 20, 2019
High virulence gene diversity in Streptococcus pyogenes isolated in Central Italy
Daniela Bencardino, Maria Chiara Di Luca, Dezemona Petrelli, Manuela Prenna, Luca Agostino Vitali
https://doi.org/10.7717/peerj.6613 PubMed 30918759
January 17, 2019
Seasonality and trend prediction of scarlet fever incidence in mainland China from 2004 to 2018 using a hybrid SARIMA-NARX model
Yongbin Wang, Chunjie Xu, Zhende Wang, Juxiang Yuan
https://doi.org/10.7717/peerj.6165 PubMed 30671295
January 14, 2019
Application of built-in adjuvants for epitope-based vaccines
Yao Lei, Furong Zhao, Junjun Shao, Yangfan Li, Shifang Li, Huiyun Chang, Yongguang Zhang
https://doi.org/10.7717/peerj.6185 PubMed 30656066
July 31, 2018
IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection
Aloysius D. Loglo, Michael Frimpong, Mabel Sarpong Duah, Fred Sarfo, Francisca N. Sarpong, Bernadette Agbavor, Justice K. Boakye-Appiah, Kabiru M. Abass, Mathias Dongyele, Margaret Frempong, Sacha Pidot, Mark Wansbrough-Jones, Timothy P. Stinear, Virginie Roupie, Kris Huygen, Richard O. Phillips
https://doi.org/10.7717/peerj.5294 PubMed 30090691
July 25, 2018
In vitro activities of antifungals alone and in combination with tigecycline against Candida albicans biofilms
Mayram Hacioglu, Ayse Seher Birteksoz Tan, Sibel Dosler, Nese Inan, Gulten Otuk
https://doi.org/10.7717/peerj.5263 PubMed 30065873
July 10, 2018
Use of design of experiments to optimize the production of microbial probiotic biofilms
Barbara Speranza, Arcangelo Liso, Maria Rosaria Corbo
https://doi.org/10.7717/peerj.4826 PubMed 30018849
June 25, 2018
Forecasting influenza epidemics by integrating internet search queries and traditional surveillance data with the support vector machine regression model in Liaoning, from 2011 to 2015
Feng Liang, Peng Guan, Wei Wu, Desheng Huang
https://doi.org/10.7717/peerj.5134 PubMed 29967755
May 4, 2018
The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia
Marion Herisse, Jessica L. Porter, Romain Guerillot, Takehiro Tomita, Anders Goncalves Da Silva, Torsten Seemann, Benjamin P. Howden, Timothy P. Stinear, Sacha J. Pidot
https://doi.org/10.7717/peerj.4784 PubMed 29740520
March 30, 2018
Acidification increases abundances of Vibrionales and Planctomycetia associated to a seaweed-grazer system: potential consequences for disease and prey digestion efficiency
Tania Aires, Alexandra Serebryakova, Frédérique Viard, Ester A. Serrão, Aschwin H. Engelen
https://doi.org/10.7717/peerj.4377 PubMed 29610702
January 30, 2018
Comparative proteomics reveals that YK51, a 4-Hydroxypandurantin-A analogue, downregulates the expression of proteins associated with dengue virus infection
Wei-Lian Tan, Yean Kee Lee, Yen Fong Ho, Rohana Yusof, Noorsaadah Abdul Rahman, Saiful Anuar Karsani
https://doi.org/10.7717/peerj.3939 PubMed 29404200
December 18, 2017
Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine
Andrzej Hudecki, Joanna Gola, Saeid Ghavami, Magdalena Skonieczna, Jarosław Markowski, Wirginia Likus, Magdalena Lewandowska, Wojciech Maziarz, Marek J. Los
https://doi.org/10.7717/peerj.4125 PubMed 29302386
December 14, 2017
CD4 count and tuberculosis risk in HIV-positive adults not on ART: a systematic review and meta-analysis
Penelope K. Ellis, Willam J. Martin, Peter J. Dodd
https://doi.org/10.7717/peerj.4165 PubMed 29259846
December 6, 2017
Integrated downstream regulation by the quorum-sensing controlled transcription factors LrhA and RcsA impacts phenotypic outputs associated with virulence in the phytopathogen Pantoea stewartii subsp. stewartii
Duy An Duong, Ann M. Stevens
https://doi.org/10.7717/peerj.4145 PubMed 29230372
December 4, 2017
Molecular evolution of virulence genes and non-virulence genes in clinical, natural and artificial environmental Legionella pneumophila isolates
Xiao-Yong Zhan, Qing-Yi Zhu
https://doi.org/10.7717/peerj.4114 PubMed 29226035
November 30, 2017
Diagnosis value of aberrantly expressed microRNA profiles in lung squamous cell carcinoma: a study based on the Cancer Genome Atlas
Sheng Yang, Jing Sui, Geyu Liang
https://doi.org/10.7717/peerj.4101 PubMed 29204322
November 29, 2017
Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production
Juwairiah Remali, Nurul ‘Izzah Mohd Sarmin, Chyan Leong Ng, John J.L. Tiong, Wan M. Aizat, Loke Kok Keong, Noraziah Mohamad Zin
https://doi.org/10.7717/peerj.3738 PubMed 29201559
November 27, 2017
Impacts of diarrhea on the immune system, intestinal environment, and expression of PGRPs in New Zealand rabbits
Yang Chen, Bohao Zhao, Yuwei Wu, Shuaishuai Hu, Lin Mu, Cigen Zhu, Yulai Pan, Xinsheng Wu
https://doi.org/10.7717/peerj.4100 PubMed 29201570
November 15, 2017
Virus like particles as a platform for cancer vaccine development
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
https://doi.org/10.7717/peerj.4053 PubMed 29158984
November 13, 2017
Generation and characterization of cross neutralizing human monoclonal antibody against 4 serotypes of dengue virus without enhancing activity
Subenya Injampa, Nataya Muenngern, Chonlatip Pipattanaboon, Surachet Benjathummarak, Khwanchit Boonha, Hathairad Hananantachai, Waranya Wongwit, Pongrama Ramasoota, Pannamthip Pitaksajjakul
https://doi.org/10.7717/peerj.4021 PubMed 29152418
November 6, 2017
HCV core antigen is an alternative marker to HCV RNA for evaluating active HCV infection: implications for improved diagnostic option in an era of affordable DAAs
Rujipat Wasitthankasem, Preeyaporn Vichaiwattana, Chompoonut Auphimai, Nipaporn Siripon, Sirapa Klinfueng, Pisit Tangkijvanich, Sompong Vongpunsawad, Yong Poovorawan
https://doi.org/10.7717/peerj.4008 PubMed 29134150
October 24, 2017
Statins: antimicrobial resistance breakers or makers?
Humphrey H.T. Ko, Ricky R. Lareu, Brett R. Dix, Jeffery D. Hughes
https://doi.org/10.7717/peerj.3952 PubMed 29085751
October 5, 2017
Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin against Streptococcus pneumoniae
Hassan Mahmood Jindal, Keivan Zandi, Kien Chai Ong, Rukumani Devi Velayuthan, Sara Maisha Rasid, Chandramathi Samudi Raju, Shamala Devi Sekaran
https://doi.org/10.7717/peerj.3887 PubMed 29018620
August 21, 2017
The effects of allogenic stem cells in a murine model of hind limb diabetic ischemic tissue
Jesús Álvarez García, Soledad García Gómez-Heras, Luis Riera del Moral, Carlota Largo, Damián García-Olmo, Mariano García-Arranz
https://doi.org/10.7717/peerj.3664 PubMed 28852591
July 20, 2017
A highly pathogenic porcine reproductive and respiratory syndrome virus candidate vaccine based on Japanese encephalitis virus replicon system
Pingsheng Hu, Xiaoming Chen, Lihong Huang, Shukai Liu, Fuyu Zang, Jinchao Xing, Youyue Zhang, Jiaqi Liang, Guihong Zhang, Ming Liao, Wenbao Qi
https://doi.org/10.7717/peerj.3514 PubMed 28740748
July 19, 2017
Identification and characterization of Streptomyces flavogriseus NJ-4 as a novel producer of actinomycin D and holomycin
Zhaohui Wei, Chao Xu, Juan Wang, Fengxia Lu, Xiaomei Bie, Zhaoxin Lu
https://doi.org/10.7717/peerj.3601 PubMed 28740758
June 27, 2017
Microplasma-assisted hydrogel fabrication: A novel method for gelatin-graphene oxide nano composite hydrogel synthesis for biomedical application
Mantosh Kumar Satapathy, Wei-Hung Chiang, Er-Yuan Chuang, Chih-Hwa Chen, Jia-Liang Liao, Huin-Ning Huang
https://doi.org/10.7717/peerj.3498 PubMed 28663938
May 17, 2017
Preservation media, durations and cell concentrations of short-term storage affect key features of human adipose-derived mesenchymal stem cells for therapeutic application
Fengli Zhang, Huaijuan Ren, Xiaohu Shao, Chao Zhuang, Yantian Chen, Nianmin Qi
https://doi.org/10.7717/peerj.3301 PubMed 28533959
April 26, 2017
Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli
Diana Machado, Laura Fernandes, Sofia S. Costa, Rolando Cannalire, Giuseppe Manfroni, Oriana Tabarrini, Isabel Couto, Stefano Sabatini, Miguel Viveiros
https://doi.org/10.7717/peerj.3168 PubMed 28516003