Academic Editor

David Meyre


Summary

David Meyre completed a PhD in quantitative plant genetics in France. Since 2001, he has been working on the elucidation of the genetic bases of obesity and type 2 diabetes. In 2004, he published the first family-based genome-wide scans for childhood and severe adult obesity. He completed the two first successful positional cloning efforts for childhood and severe adult obesity, which identified the positional candidate genes ENPP1 and PCSK1. In 2007, he contributed to the identification of the major susceptibility gene for polygenic obesity FTO. In 2009, he published the first genome-wide association study of extreme obesity in the French population and identified four novel susceptibility-loci. In 2010, he conducted the first genome-wide association meta-analysis for early-onset extreme obesity in German and French populations. In 2012, he identified the third more common form of monogenic obesity (PCSK1 partial deficiency) and demonstrated an important role of the lipid sensor GPR120 in human obesity. He also discovered the first molecular link between obesity and major depression. In 2013, he discovered a novel gene (SIM1) responsible for a syndromic Mendelian form of childhood obesity. In 2016, he discovered that physical activity can blunt the effect of the obesity predisposing gene FTO in diverse ethnic groups. He also demonstrated that genes can predict the outcomes of different types of bariatric surgery.

Diabetes & Endocrinology Genetics Genomics Nutrition Statistics

Institution affiliations

Work details

Associate Professor

McMaster University
Department of Clinical Epidemiology & Biostatistics
With 164 articles published up to date (94 appeared in top-tier journals including Nature, Science, Nature Genetics...), 17,400 citations and a H-index of 53, Dr Meyre is an international expert in genetic epidemiology of obesity and type 2 diabetes. Dr Meyre is developing a multidisciplinary obesity genetic research program at McMaster University to provide an exhaustive picture of the etiology of this complex disorder and to equip the decision makers with the appropriate tools in order to tackle obesity and its complications worldwide. His current research interests include 1) gene identification in diverse ethnic groups 2) gene x environment interactions 3) epigenetics 4) evolutionary genetics 5) molecular physiology 6) systems biology 7) development of new methods and guidelines 8) knowledge synthesis 9) knowledge translation and 10) evidence-based personalized prevention and medicine.

PeerJ Contributions

June 23, 2016
2 citations
241 downloads
1,018 views
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https://doi.org/10.7717/peerj.2090 PubMed 27366637
March 24, 2015
19 citations
1,261 downloads
4,791 views
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https://doi.org/10.7717/peerj.856 PubMed 25825681

Academic Editor on

July 13, 2017
67 downloads
389 views
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https://doi.org/10.7717/peerj.3414 PubMed 28717589