David Meyre completed a PhD in quantitative plant genetics in France. Since 2001, he has been working on the elucidation of the genetic bases of obesity and type 2 diabetes. In 2004, he published the first family-based genome-wide scans for childhood and severe adult obesity. He completed the two first successful positional cloning efforts for childhood and severe adult obesity, which identified the positional candidate genes ENPP1 and PCSK1. In 2007, he contributed to the identification of the major susceptibility gene for polygenic obesity FTO. In 2009, he published the first genome-wide association study of extreme obesity in the French population and identified four novel susceptibility-loci. In 2010, he conducted the first genome-wide association meta-analysis for early-onset extreme obesity in German and French populations. In 2012, he identified the third more common form of monogenic obesity (PCSK1 partial deficiency) and demonstrated an important role of the lipid sensor GPR120 in human obesity. He also discovered the first molecular link between obesity and major depression. In 2013, he discovered a novel gene (SIM1) responsible for a syndromic Mendelian form of childhood obesity. In 2016, he discovered that physical activity can blunt the effect of the obesity predisposing gene FTO in diverse ethnic groups. He also demonstrated that genes can predict the outcomes of different types of bariatric surgery.