I am working on cancer biology and therapy. My past work led me to uncover the role of ligand-independent BCR signaling in lymphoma, identifying the antibody heavy chain gene as an oncogene (Corcos et al., Curr Biol 1995). I have also demonstrated in 1991, while working on myc, the existence of oncogene-induced genetic instability (Denis et al., Oncogene, 1991), currently considered as a major mechanism for cancer evolution. One of my aims is to protect normal cells from the effects of cancer chemotherapy. More recently, I have found that the cancer risk related to mammography screening is underestimated, suggesting that medical x-rays are the main factor in the worldwide breast cancer epidemics.