Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Gene Therapy and Cancer Group
The research of the group focuses on the study of the molecular and cellular basis of pancreatic ductal adenocarcinoma and the development of novel experimental therapies based on gene transfer and virotherapy.
The main research lines are: 1)Identify specific cellular pathways and molecular determinants altered in pancreatic tumors.
2) Development of antitumoral therapies based on oncolytic adenovirus. Main interest is devoted to the search for sensitizers of adenoviral oncolysis and to study their mechanisms of synergie. Special emphasis is also applied to engineer tumor-selective oncolytic adenoviruses.
3) Explore novel non-viral experimental therapies for pancreatic tumors. Preclinical testing of the newly developed therapies is studied in genetically-modified mouse models and in orthotopic xenografts. Some of the animal models are specially designed to allow for the non-invasive imaging of tumor progression and metastatic processes.
4) Development of gene therapy strategies to study rare genetic diseases.