Anthony Raphael
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Anthony P Raphael


Currently I have a joint appointment at Harvard Medical School, Wellman Centre for Photomedicine, Massachusetts General Hospital, and The University of Queensland. I am based in Boston.

Since the start of my PhD in 2008 and following its award in 2012, I have consistently contributed to the field of biomedical engineering and topical drug delivery through high impact publications and patents. My research focus at the Dermatology Research Centre is the development of novel technologies for enhanced treatment of skin disease. This has resulted in multiple papers and patents, leading to awards at national/international conferences, an early career research grant and Australia's prestigious NHMRC Early Career Fellowship.

Currently my professional pathway has been on the focus of micro-devices for topical drug delivery based on a biological, immunological and biophysical understanding of the skin. To further develop my skill set I began a joint research position at Assoc. Prof. Charles Lin’s Group at Harvard Medical School, Wellman Centre for Photomedicine, Massachusetts General Hospital. My personal goals of the projects are to develop my expertise in noninvasive imaging, biomedical optics and single cell diagnostics. The appointment will complement my current career path by strengthening my biomedical engineering expertise and furthering my fundamental knowledge of cell interaction and characterisation.

Dermatology Drugs & Devices Immunology Oncology Pharmacology

Institution affiliations

Work details

Research Fellow

Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital
My contribution to the development of a micro-biopsy platform set the groundwork for my current Fellowship and appointment at the Harvard/MGH. Here I am investigating the utility of minimally invasive micro-extraction techniques for image-guided cell characterisation in bone marrow. The aim is to extract specific hematopoietic stem cells and residual cancer stem cells in addition to their local microenvironement (niche), respectively, for spatial transcriptomics. By gaining an understanding of diseased cells within their cellular niche, it is hypothesised that the mechanisms of chemoresistance can be determined and methods to overcome it – either through improved drug treatments or by targeted disruption of the niche.

Research Fellow

Dermatology Research Centre, School of Medicine, Translational Research Centre, The University of Queensland
Following my PhD, I moved to the Dermatology Research Centre to focus on topical treatment of skin disease. I utilised non-invasive optical techniques for assessment of nanoparticle penetration, toxicity and removal within skin. In particular, my research provided information on nanoparticle infiltration and persistence within injured human skin. However, my primary focus was on the development of an elongated microparticle delivery platform for field-directed delivery of topical drugs, vaccines and particles with the emphasis on managing non-melanoma skin cancer. The motivation behind this research was to build on the benefits of microneedle delivery but remove the limitations of skin morphology, lesion size and complicated formulation requirements.